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The Supporting Information is available free of charge at Additional experimental details, calculations, materials, and methods, including tabulated data and element e-liquid and aerosol concentrations, photographs of devices and laser ablation samples, and supplementary data plots for aerosol mass generation, and cancer risk evaluations (PDF) Tables S1–S22 (XLSX) The authors declare the following competing financial interest(s): One of the authors (A.K.M.), in addition to an appointment at the University of California, Davis, is employed by a scientific consulting firm, Valeo Sciences LLC, which provides scientific advice to the government, corporations, law firms, and various scientific/professional organizations